May Research And News

We combed through multiple medical journals looking for the latest research on Integrative approach to kidney health. We know your time is valuable so we curated and summarized these studies for you. Welcome to the InKidney May Research and News.

Colchicine for CKD!  

In a multi-center, nested, case-control study in three Korean hospitals, patients with CKD stage 3 and 4 who are using drugs including colchicine, allopurinol, and febuxostat for high uric acid or chronic gout were studied over a period of 10 years. The progression of CKD was compared between 3085 compared to 11715 control patients.

Colchicine use was associated with a lower risk of adverse kidney outcomes in CKD patients with hyperuricemia, or chronic gout.

Unlike a study published two years ago in NEJM which excluded patients with advanced CKD, this study included patients with kidney function as low as 15 ml/min. Colchicine is known to anti-inflammatory. It also protects against kidney fibrosis.

There are concerns about myopathy and neuropathy with the intake of colchicine. It is, therefore, important to adjust the dose with advanced kidney disease and to be cautious when using it with patients who are on other myopathy-inducing drugs such as statin drugs.

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Long sleep duration is associated with decline in kidney function

This study is retrospective, longitudinal cohort study included 82,001 participants who visited a primary care center in Japan. Patients were categorized into CKD risk groups and sleep duration categories according to their self-reported average nightly sleep duration. The relationship between average nightly sleep duration and the incidence of composite renal outcome was studied.

Researchers found that an average sleep durations ≥8 h/night were associated with an increased risk of kidney function decline over time.

There are many reasons that connect sleep problems with poor kidney function. We summarized these in this blog.

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Risk of environmental heavy metal toxicity is higher in CKD 

In a study of 5,638 NHANES participants, lead and cadmium levels were higher in patients with CKD than those without it. This was also associated with decreased urinary lead excretion. Each decrease in estimated GFR by 10 ml/min/1.73m2 was associated with 0.05 mcg/dL increase in lead levels and 0.02 mcg/dL of cadmium levels. This association was even stronger among black participants.

The study concluded that CKD increases the susceptibility to heavy metal environmental exposure by reducing its elimination.

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