Serum Biomarkers of Iron Stores Are Associated with Increased Risk of All-Cause Mortality and Cardiovascular Events in CKD Patients, with or without Anemia
Studies in patients with heart failure with similar iron deficiency pathogenesis found that treating iron deficiency improves cardiovascular outcomes, regardless of anemia. In this study, researches evaluated a possible anemia-independent association of iron stores with outcomes in individuals with non-dialysis CKD. They showed that iron deficiency, as reflected by transferrin saturation index, was associated with higher risk of mortality and cardiovascular events in patients with CKD, with or without anemia.
Managing iron deficiency in CKD patients may have benefits beyond anemia managements.
Read Study
Intestinal phosphorus absorption with dietary intake typical for the general population is not detectably different in patients with moderate CKD compared with control subjects, despite lower 1,25-dihydroxyvitamin D level
Phosphorus plays a crucial role in CKD as we discussed in our blog. Yet, it is not clear if the progression of CKD affects intestinal phosphorus absorption. This study determined intestinal phosphorus absorption in patients with moderate CKD compared with healthy adults using a direct 33P radiotracer method in a controlled feeding. Intestinal phosphorus absorption with dietary intake typical for the general population is not detectably different in patients with moderate CKD compared with control subjects, despite lower 1,25-dihydroxyvitamin D levels. The reason why intestinal phosphorus absorption does not decrease with declining kidney function is still poorly understood. It is, therefore crucial to identify other factors that influence intestinal phosphorus absorption in patients with CKD other than 1,25-dihydroxyvitamin D.
Read Study
Amiloride decreases urinary calcium in healthy volunteers under high-sodium diet
In patients on high sodium/low potassium diet (the standard American diet), amiloride significantly reduced urinary calcium. This was most probably mediated by increased proximal Ca reabsorption. This study points to the potential use of amiloride alone or in combination with thiazide diuretics to decrease urinary calcium more efficiently. This could be useful in preventing kidney stones in patients who are not able to prevent kidney stones by dietary modifications alone.
Read our blog about the integrative approach to kidney stones.
Read Study
