Sex-specific Associations of Sex Hormone Binding Globulin with CKD and Kidney Function: A Univariable and Multivariable Mendelian Randomization Study in the UK Biobank

Do sex hormones play any role in the progression of kidney disease? It has been long observed that CKD is more prevalent in women; however, the progression of CKD is much faster in men. This study looked at the sex hormone binding globulin (SHBG) using Mendelian randomization. Higher SHBG levels were associated with lower risk for CKD and better renal function in men but not in women. “Identifying factors affecting SHBG, and underlying pathways, could provide new insights for prevention and treatment strategies.”
https://jasn.asnjournals.org/content/32/3/686

Water intake and progression of chronic kidney disease: the CKD-REIN cohort study

How does water intake affect the progression of kidney disease? In this study, researchers found that “in patients with CKD, the relation between plain water intake and progression to kidney failure appears to be U-shaped. Both low and high intake may not be beneficial in CKD.”
https://academic.oup.com/ndt/advance-article-abstract/doi/10.1093/ndt/gfab036/6134139?redirectedFrom=fulltext

Anti-neutrophil cytoplasmic antibody associated glomerulonephritis complicating treatment with hydralazine

Medications can sometimes be triggers to autoimmune kidney diseases. This article talks specifically about hydralazine which is an old blood pressure medication that is used often by our cardiology colleagues specifically in patients with advanced kidney disease who are often not candidates for ACE inhibitors or ARB therapy.
https://www.kidney-international.org/article/S0085-2538(21)00379-3/fulltext?WT_MC_ID=ITL